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Image Search Results
Journal: PLoS ONE
Article Title: Phosphorylated fibronectin enhances cell attachment and upregulates mechanical cell functions
doi: 10.1371/journal.pone.0218893
Figure Lengend Snippet: A : Cell spreading assay on fibronectin (Fn) fragments as defined in . B : Inhibition of αvβ3 and α5β1 integrins on CKII-treated fibronectin. Fibroblasts were preincubated for 10 min with 2.5μg/ml integrin isoform-specific anti-αvβ3 antibodies, anti-α5 antibodies, or 10μg/ml cyclic RGD. Cell spreading area of single cells was measured 30 min after seeding. Statistical comparison done with Student’s t -test between pair of samples connected with lines on the column plots: ***, p-value<0.005; **, p-value<0.01; *, p-value<0.05; not significant (ns).
Article Snippet: The
Techniques: Inhibition, Comparison
Journal: PLoS ONE
Article Title: Phosphorylated fibronectin enhances cell attachment and upregulates mechanical cell functions
doi: 10.1371/journal.pone.0218893
Figure Lengend Snippet: A: Sequence alignment of the FnIII 9-10 for various species, namely human, mouse, rat, bovine, chicken, pleurodeles waltl (PW), xenopus tropicalis (XT), xenopus laevis (XL) and danio rerio (DR). Experimentally determined phosphorylation sites for human fibronectin are depicted in red, predicted phosphorylation sites are shown in green. B: Structure of αvβ3 integrin headpiece docked to FnIII 9-10 . RGD (yellow) and synergy site (blue) are shown in sticks representation. C: Sequences of 20 RGD (yellow) containing human integrin ligands were analyzed -/+ 50 residues around their RGD. Shown are experimentally verified phosphor-sites. Black boxes indicate the sequences of the analyzed structures in D. D: The structures of fibronectin, vitronectin, bone sialoprotein, fibrinogen A and osteopontin were analyzed in proximity of their RGD (yellow) sites and experimentally verified phosphorylated sites (red) are highlighted.
Article Snippet: The
Techniques: Sequencing, Phospho-proteomics
Journal: Cancers
Article Title: Are Integrins Still Practicable Targets for Anti-Cancer Therapy?
doi: 10.3390/cancers11070978
Figure Lengend Snippet: Selected clinical trials of agents targeting integrins. Non-exhaustive listing of the recent most important clinical studies with integrin inhibitors and their salient features and results).
Article Snippet:
Techniques: Clinical Proteomics, Control, Activity Assay, Comparison